Wrinkle treatment with botox (botulinum toxin) is in our opinion generally not recommended, because botox causes skin glands to degenerate (which is also why botox is used to treat excessive perspiration) and the skin becomes even drier and thinner as a result. However, botox may be indicated in some cases for relaxing temporary involuntary facial movements (e.g., after facial surgery).
The use of artificial fillers such as hyaluronic acid to smooth wrinkles does restore volume, but does not change the quality of the subcutaneous tissue. The visual effect is thus limited to increase in volume; the quality of the skin or the subcutaneous tissue is not improved. And lastly, botox and fillers result in a doll-like, unnatural facial expression.